Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS12690 (cepI)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS12690
|
| NCBI Old Locus Tag | BURCENK562V_C4006 |
| Name |
cepI
|
| Replicon | ctg7180000002940B |
| Genomic location | 1508252 - 1508860 (+ strand) |
Cross-References
| RefSeq | WP_006483943.1 |
| GI | 493529928 |
| GI | 493529928 |
| NCBI Locus Tag | BURCENK562V_RS12690 |
| NCBI Old Locus Tag | BURCENK562V_C4006 |
| RefSeq | WP_006483943.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
CepI
|
| Synonyms |
N-acyl homoserine lactone synthase, CepI acyl-homoserine-lactone synthase |
| Evidence for Translation | |
| Charge (pH 7) | -5.16 |
| Kyte-Doolittle Hydrophobicity Value | -0.112 |
| Molecular Weight (kDa) | 22263.1 |
| Isoelectric Point (pI) | 5.08 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Virulence Evidence
| Source 1 | |
| Database | BGD |
| Category | Quorum sensing system |
| Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
| Host Organism | Rattus norvegicus |
| Notes | cepI mutant attenuated for virulence in agar bead model of chronic lung infection |
| Reference | 14663096 |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG003720 (981 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS12690
Search term: cepI
Search term: CepI
|
Human Homologs
References
|
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
Infect Immun 2005 Aug;73(8):4982-92
PubMed ID: 16041013
|
|
The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections.
Sokol PA, Sajjan U, Visser MB, Gingues S, Forstner J, Kooi C
Microbiology 2003 Dec;149(Pt 12):3649-3658
PubMed ID: 14663096
|