Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS12690 (cepI)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C4006
Replicon ctg7180000002940B
Genomic location 1508252 - 1508860 (+ strand)


RefSeq WP_006483943.1
GI 493529928
GI 493529928
NCBI Locus Tag BURCENK562V_RS12690
NCBI Old Locus Tag BURCENK562V_C4006
RefSeq WP_006483943.1


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms N-acyl homoserine lactone synthase, CepI
acyl-homoserine-lactone synthase
Evidence for Translation
Charge (pH 7) -5.16
Kyte-Doolittle Hydrophobicity Value -0.112
Molecular Weight (kDa) 22263.1
Isoelectric Point (pI) 5.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category Quorum sensing system
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes cepI mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 14663096

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003720 (981 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: cepI
Search term: CepI

Human Homologs


Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
Infect Immun 2005 Aug;73(8):4982-92
PubMed ID: 16041013
The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections.
Sokol PA, Sajjan U, Visser MB, Gingues S, Forstner J, Kooi C
Microbiology 2003 Dec;149(Pt 12):3649-3658
PubMed ID: 14663096