Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29130 (galE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS29130
NCBI Old Locus TagBURCENK562V_C5757
Name
galE
Replicon ctg7180000002940C
Genomic location 116260 - 117282 (- strand)
CommentBelongs to the O antigen biosynthesis gene cluster

Cross-References

RefSeq WP_006485111.1
GI 493531108
EC Number 5.1.3.2
GI 493531108
NCBI Locus Tag BURCENK562V_RS29130
NCBI Old Locus Tag BURCENK562V_C5757
RefSeq WP_006485111.1

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-glucose 4-epimerase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.16
Kyte-Doolittle Hydrophobicity Value -0.070
Molecular Weight (kDa) 36862.6
Isoelectric Point (pI) 5.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000745 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: galE

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-galactose-4-epimerase [Source:HGNC Symbol;Acc:HGNC:4116]
E-value: 4.9e-116
Percent Identity: 57.4
Ensembl 97, assembly GRCh38.p12
UDP-galactose-4-epimerase [Source:HGNC Symbol;Acc:HGNC:4116]
E-value: 4.9e-116
Percent Identity: 57.4

References

Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis.
Ortega X, Hunt TA, Loutet S, Vinion-Dubiel AD, Datta A, Choudhury B, Goldberg JB, Carlson R, Valvano MA
J Bacteriol 2005 Feb;187(4):1324-33
PubMed ID: 15687196