Burkholderia cenocepacia J2315, BCAM0926

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0926
NCBI Locus TagQU43_RS59005
Name
Replicon chromosome 2
Genomic location 1021708 - 1024851 (- strand)
CommentMember of rnd-8 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-8
Comment Major RND-8 substrate is tobramycin (in biofilm grown cells)

Cross-References

RefSeq WP_006489059.1
GI 206562781
Entrez 6928661
GI 206562781
INSDC CAR54783.1
NCBI Locus Tag QU43_RS59005
NCBI Old Locus Tag BCAM0926
RefSeq WP_006489059.1,GeneID
UniParc UPI00017B9C8D
UniProtKB Acc B4EF71
UniProtKB ID B4EF71_BURCJ
UniRef100 UniRef100_B4EF71
UniRef50 UniRef50_P31224
UniRef90 UniRef90_B4EF71

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-8 efflux system transporter protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.69
Kyte-Doolittle Hydrophobicity Value 0.345
Molecular Weight (kDa) 111959.7
Isoelectric Point (pI) 9.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001444 (2569 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0926

References

Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis.
Sass A, Marchbank A, Tullis E, Lipuma JJ, Mahenthiralingam E
BMC Genomics 2011 Jul 22;12:373
PubMed ID: 21781329
Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825