Burkholderia cenocepacia J2315, BCAL1932 (arnC)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL1932
NCBI Locus Tag	QU43_RS46205
Name	arnC
Replicon	chromosome 1
Genomic location	2131793 - 2132830 (+ strand)
Comment	In PMID:27597847: arnT, arnB, arnC, arnA1, arnA2, and BCAL1935 located in the arn gene cluster harbored significantly low frequencies of transposon insertions (TraDIS). They were therefore categorized as essential by the authors.

Cross-References

RefSeq	WP_006482860.1
GI	206560296
Entrez	6933310
GI	206560296
INSDC	CAR52233.1
NCBI Locus Tag	QU43_RS46205
NCBI Old Locus Tag	BCAL1932
RefSeq	WP_006482860.1,GeneID
UniParc	UPI00017B9221
UniProtKB Acc	B4EB18
UniProtKB ID	B4EB18_BURCJ
UniRef100	UniRef100_A0A0D1D8J9
UniRef50	UniRef50_Q8XZS4
UniRef90	UniRef90_A0A095DZ33

Product

Feature Type	CDS
Coding Frame	1
Product Name	Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Product Name Confidence: Class 1
Synonyms	putative undecaprenyl-phosphate 4-deoxy-4-formamido-l-arabinose transferase
Evidence for Translation
Charge (pH 7)	1.62
Kyte-Doolittle Hydrophobicity Value	0.113
Molecular Weight (kDa)	38426.0
Isoelectric Point (pI)	7.69

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 548 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001694 (652 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL1932 Search term: arnC Search term: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

Human Homologs

References

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability. Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA J Bacteriol 2007 May;189(9):3639-44 PubMed ID: 17337576

PubMed ID: 22742453

Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS. Wong YC, Abd El Ghany M, Naeem R, Lee KW, Tan YC, Pain A, Nathan S Front Microbiol 2016;7:1288 PubMed ID: 27597847