Burkholderia cenocepacia J2315, BCAL1674

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL1674
NCBI Locus TagQU43_RS44895
Name
Replicon chromosome 1
Genomic location 1828787 - 1830022 (+ strand)
Comment Major RND-3 substrates are nalidixic acid, ciprofloxacin, tobramycin, chlorhexidine
Comment
CommentMember of rnd-3 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-3

Cross-References

RefSeq YP_002230800.1
GI 206560036
Entrez 6931932
GI 206560036
NCBI Locus Tag QU43_RS44895
NCBI Old Locus Tag BCAL1674
RefSeq YP_002230800.1
UniProtKB Acc B4E8U6
UniProtKB ID B4E8U6_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-3 efflux system membrane fusion protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 12.70
Kyte-Doolittle Hydrophobicity Value -0.232
Molecular Weight (kDa) 43914.6
Isoelectric Point (pI) 10.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
amrA amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. ARO:3002982 protein homolog model Strict 0.0 77.01 1.2.1

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001443 (622 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1674

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825