Burkholderia pseudomallei K96243, BPSS1832 (bceD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1832
Name
bceD
Replicon chromosome 2
Genomic location 2492247 - 2492681 (- strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq YP_111836.1
GI 53722851
Entrez 3095992
GI 53722851
INSDC CAH39308.1
NCBI Locus Tag BPSS1832
RefSeq YP_111836.1,GeneID
UniParc UPI000043BE45
UniProtKB Acc Q63J86
UniProtKB ID Q63J86_BURPS
UniRef100 UniRef100_A3NMP3
UniRef50 UniRef50_Q2T7V4
UniRef90 UniRef90_Q2T7V4

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphotyrosine phosphatase BceD
Product Name Confidence: Class 2
Synonyms exopolysaccharide (EPS) biosynthesis-likelow molecular weight protein-tyrosine-phosphatase
Evidence for Translation
Charge (pH 7) -0.14
Kyte-Doolittle Hydrophobicity Value -0.206
Molecular Weight (kDa) 16076.2
Isoelectric Point (pI) 6.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 305 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004849 (632 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1832
Search term: bceD

Human Homologs

References

Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formation.
Ferreira AS, Leitão JH, Sousa SA, Cosme AM, Sá-Correia I, Moreira LM
Appl Environ Microbiol 2007 Jan;73(2):524-34
PubMed ID: 17114319
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity.
Andrade A, Tavares-Carreón F, Khodai-Kalaki M, Valvano MA
Appl Environ Microbiol 2016 Feb 1;82(3):843-56
PubMed ID: 26590274
The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line.
Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM
Infect Immun 2015 Feb;83(2):812-21
PubMed ID: 25486990