Burkholderia pseudomallei K96243, BPSS1726 (acnA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1726
Name
acnA
Replicon chromosome 2
Genomic location 2365086 - 2367803 (+ strand)

Cross-References

RefSeq YP_111732.1
GI 53722747
Entrez 3096598
GI 53722747
INSDC CAH39200.1
NCBI Locus Tag BPSS1726
RefSeq YP_111732.1,GeneID
UniParc UPI000043BDDD
UniProtKB Acc Q63JJ0
UniProtKB ID Q63JJ0_BURPS
UniRef100 UniRef100_A0A097XM97
UniRef50 UniRef50_P25516
UniRef90 UniRef90_Q2T7J6

Product

Feature Type CDS
Coding Frame 1
Product Name
aconitate hydratase
Synonyms
Evidence for Translation
Charge (pH 7) 2.81
Kyte-Doolittle Hydrophobicity Value -0.186
Molecular Weight (kDa) 98517.0
Isoelectric Point (pI) 7.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003060 (1309 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1726
Search term: acnA

Human Homologs

Ensembl 97, assembly GRCh38.p12
aconitase 1 [Source:HGNC Symbol;Acc:HGNC:117]
E-value: 1.5e-249
Percent Identity: 50.4
Ensembl 97, assembly GRCh38.p12
aconitase 1 [Source:HGNC Symbol;Acc:HGNC:117]
E-value: 1.5e-249
Percent Identity: 50.4
Ensembl 97, assembly GRCh38.p12
aconitase 1 [Source:HGNC Symbol;Acc:HGNC:117]
E-value: 1.5e-249
Percent Identity: 50.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268