Burkholderia pseudomallei K96243, BPSS1506 (tagC-5)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
Replicon chromosome 2
Genomic location 2056626 - 2057378 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434).


RefSeq YP_111513.1
GI 53722528
Entrez 3094883
GI 53722528
INSDC CAH38979.1
NCBI Locus Tag BPSS1506
RefSeq YP_111513.1,GeneID
UniParc UPI000043BD05
UniProtKB Acc Q63K59
UniRef100 UniRef100_A0A095RNU2
UniRef50 UniRef50_Q2T6Z2
UniRef90 UniRef90_Q3JL50


Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagC-5
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.7 kDa, pI 5.86, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.8 kDa, pI 6.01, PMID:21960737)
Charge (pH 7) 4.24
Kyte-Doolittle Hydrophobicity Value -0.076
Molecular Weight (kDa) 26295.4
Isoelectric Point (pI) 8.09

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0429
Category T6SS-1
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Reference 17984080

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 18 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019352 (319 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1506
Search term: tagC-5

Human Homologs


In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434