Burkholderia pseudomallei K96243, BPSS0097 (tssB-2)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
Replicon chromosome 2
Genomic location 117729 - 118268 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-2 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-5 cluster later (PMID:22007185)


RefSeq YP_110120.1
GI 53721135
Entrez 3096823
GI 53721135
INSDC CAH37543.1
NCBI Locus Tag BPSS0097
RefSeq YP_110120.1,GeneID
UniParc UPI000043B7B3
UniProtKB Acc Q63P49
UniRef100 UniRef100_A0A069B627
UniRef50 UniRef50_L7ZP21
UniRef90 UniRef90_Q2T926


Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssB-2
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -1.76
Kyte-Doolittle Hydrophobicity Value -0.303
Molecular Weight (kDa) 19671.4
Isoelectric Point (pI) 5.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 107 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020412 (310 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0097
Search term: tssB-2

Human Homologs


In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434