Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSL1021
|
Name |
ppa
|
Replicon | chromosome 1 |
Genomic location | 1190916 - 1191443 (+ strand) |
RefSeq | YP_107649.1 |
GI | 53718663 |
Entrez | 3094000 |
GI | 53718663 |
INSDC | CAH35017.1 |
NCBI Locus Tag | BPSL1021 |
RefSeq | YP_107649.1,GeneID |
UniParc | UPI000043AE47 |
UniProtKB Acc | Q63W67 |
UniProtKB ID | Q63W67_BURPS |
UniRef100 | UniRef100_A0A095QE80 |
UniRef50 | UniRef50_P0A7B0 |
UniRef90 | UniRef90_Q143A4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
inorganic pyrophosphatase
|
Synonyms | |
Evidence for Translation |
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (21.0 kDa, pI 5.25, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (20.8 kDa, pI 5.02, PMID:21960737)
|
Charge (pH 7) | -3.32 |
Kyte-Doolittle Hydrophobicity Value | -0.071 |
Molecular Weight (kDa) | 19161.0 |
Isoelectric Point (pI) | 5.28 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3GVF | HYDROLASE | 03/30/09 | 1.7 Angstrom crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei bound with phosphate | BURKHOLDERIA PSEUDOMALLEI 1710B | 1.75 | X-RAY DIFFRACTION | 100.0 |
3EJ2 | HYDROLASE | 09/17/08 | Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound 5-amino-1-(4-chlorophenyl)-1h-pyrazole-4-carbonitrile, H32 crystal form | BURKHOLDERIA PSEUDOMALLEI 1710B | 2.12 | X-RAY DIFFRACTION | 100.0 |
3EJ0 | HYDROLASE | 09/17/08 | Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound N-(pyridin-3-ylmethyl) aniline, H32 crystal form | BURKHOLDERIA PSEUDOMALLEI 1710B | 1.96 | X-RAY DIFFRACTION | 100.0 |
3EIY | HYDROLASE | 09/17/08 | Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound pyrophosphate | BURKHOLDERIA PSEUDOMALLEI 1710B | 2.1 | X-RAY DIFFRACTION | 100.0 |
3D63 | HYDROLASE | 05/18/08 | Crystal structure of inorganic pyrophosphatase from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.3 | X-RAY DIFFRACTION | 100.0 |
3EIZ | HYDROLASE | 09/17/08 | Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei, H32 crystal form | BURKHOLDERIA PSEUDOMALLEI 1710B | 1.88 | X-RAY DIFFRACTION | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile | DB07291 | DrugBank | 5.1.5 | Q3JUV5 | Inorganic pyrophosphatase | 100.0 | 175 | 1.1e-97 |
N-(pyridin-3-ylmethyl)aniline | DB06851 | DrugBank | 5.1.5 | Q3JUV5 | Inorganic pyrophosphatase | 100.0 | 175 | 1.1e-97 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 483 genera
|
Burkholderia Ortholog Group |
BG002287 (655 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSL1021
Search term: ppa
Search term: inorganic pyrophosphatase
|
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
|