Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS05090 (paaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS05090
NCBI Old Locus TagBURCENK562V_C6728
Name
paaA
Replicon ctg7180000002942
Genomic location 4662 - 5660 (+ strand)

Cross-References

RefSeq WP_006482888.1
GI 493528871
GI 493528871
NCBI Locus Tag BURCENK562V_RS05090
NCBI Old Locus Tag BURCENK562V_C6728
RefSeq WP_006482888.1

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylacetate-CoA oxygenase subunit PaaA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.71
Kyte-Doolittle Hydrophobicity Value -0.425
Molecular Weight (kDa) 37042.6
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category Phenylacetic acid catabolism
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes paaA mutation diminishes virulence in the C. elegans model of infection
Reference 18776009

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000240 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: paaA

Human Homologs

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ, Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST
J Bacteriol 2008 Nov;190(21):7209-18
PubMed ID: 18776009