Burkholderia cenocepacia J2315, BCAL0274 (mrcA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0008658 | penicillin binding |
Inferred from Sequence Model
Term mapped from: InterPro:PF00905
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| MetaCyc | peptidoglycan biosynthesis IV (Enterococcus faecium) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | peptidoglycan biosynthesis II (staphylococci) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00550 | Peptidoglycan biosynthesis | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bcj01501 | beta-Lactam resistance | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bcj00550 | Peptidoglycan biosynthesis | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | peptidoglycan biosynthesis V (β-lactam resistance) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | peptidoglycan biosynthesis III (mycobacteria) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bcj01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| TIGRFAM | TIGR02074 | PBP_1a_fam: penicillin-binding protein, 1A family | 86 | 727 | 8.9E-190 | ||
| Gene3D | G3DSA:2.40.50.140 | 368 | 439 | 2.2E-23 | |||
| Pfam | PF00912 | Transglycosylase | IPR001264 | Glycosyl transferase, family 51 | 78 | 250 | 7.7E-66 |
| Pfam | PF17092 | Penicillin-binding protein OB-like domain | IPR031376 | Penicillin-binding protein, OB-like domain | 337 | 441 | 7.9E-24 |
| Pfam | PF00905 | Penicillin binding protein transpeptidase domain | IPR001460 | Penicillin-binding protein, transpeptidase | 447 | 688 | 5.6E-37 |
| SUPERFAMILY | SSF56601 | IPR012338 | Beta-lactamase/transpeptidase-like | 232 | 743 | 4.86E-118 | |
| Gene3D | G3DSA:1.10.3810.10 | IPR036950 | Penicillin binding protein transglycosylase domain | 70 | 265 | 2.4E-78 | |
| SUPERFAMILY | SSF53955 | IPR023346 | Lysozyme-like domain superfamily | 63 | 273 | 3.94E-78 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.