Burkholderia mallei ATCC 23344, BMAA1548 (bsaL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia mallei ATCC 23344
GCF_000011705.1|latest
Locus Tag
BMAA1548
Name
bsaL
Synonym: sctF
Replicon chromosome 2
Genomic location 1677403 - 1677672 (+ strand)
CommentThis gene is part of the Burkholderia mallei type III secretion system T3SS-3 gene locus.

Cross-References

RefSeq YP_106136.1
GI 53716322
NCBI Locus Tag BMAA1548
RefSeq YP_106136.1,GeneID

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system outer rod/major needle component BsaL (T3SS-3)
Product Name Confidence: Class 2
Synonyms type III secretion system protein BsaL
Evidence for Translation
Charge (pH 7) -2.02
Kyte-Doolittle Hydrophobicity Value -0.620
Molecular Weight (kDa) 9923.9
Isoelectric Point (pI) 4.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2G0U UNKNOWN FUNCTION 02/13/06 Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 98.8

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019858 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMAA1548
Search term: bsaL

Human Homologs

References

Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei.
Zhang L, Wang Y, Picking WL, Picking WD, De Guzman RN
J Mol Biol 2006 Jun 2;359(2):322-30
PubMed ID: 16631790
Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH.
Wang Y, Ouellette AN, Egan CW, Rathinavelan T, Im W, De Guzman RN
J Mol Biol 2007 Aug 31;371(5):1304-14
PubMed ID: 17617421
The response of type three secretion system needle proteins MxiHDelta5, BsaLDelta5, and PrgIDelta5 to temperature and pH.
Barrett BS, Picking WL, Picking WD, Middaugh CR
Proteins 2008 Nov 15;73(3):632-43
PubMed ID: 18491382