Burkholderia cenocepacia J2315, BCAM2193 (mmsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF14833
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01692
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03446
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF14833
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01692
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03446
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG bcj00280 Valine, leucine and isoleucine degradation 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
TIGRFAM TIGR01692 HIBADH: 3-hydroxyisobutyrate dehydrogenase IPR011548 3-hydroxyisobutyrate dehydrogenase 5 291 8.9E-132
Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 2 161 1.8E-52
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1 161 5.26E-49
Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain 164 291 2.3E-36
ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site 5 18 -
Gene3D G3DSA:1.10.1040.10 IPR013328 6-phosphogluconate dehydrogenase, domain 2 164 297 9.1E-50
SUPERFAMILY SSF48179 IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 163 292 4.65E-41
Gene3D G3DSA:3.40.50.720 1 162 1.8E-59
PIRSF PIRSF000103 IPR015815 3-hydroxyisobutyrate dehydrogenase-related 1 299 1.5E-88

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.