Burkholderia cenocepacia J2315, BCAM1262 (ilvD)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00920	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009082	branched-chain amino acid biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00012	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004160	dihydroxy-acid dehydratase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00012	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	bcj01230	Biosynthesis of amino acids	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj00290	Valine, leucine and isoleucine biosynthesis	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj01110	Biosynthesis of secondary metabolites	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj00770	Pantothenate and CoA biosynthesis	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		L-isoleucine biosynthesis III	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		L-isoleucine biosynthesis II	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bcj01130	Biosynthesis of antibiotics	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG (InterPro)	00290	Valine, leucine and isoleucine biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		L-isoleucine biosynthesis IV	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG (InterPro)	00770	Pantothenate and CoA biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		pyruvate fermentation to isobutanol (engineered)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bcj01100	Metabolic pathways	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj01210	2-Oxocarboxylic acid metabolism	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Coils	Coil				617	619	-
ProSitePatterns	PS00886	Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.	IPR020558	Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site	122	132	-
Pfam	PF00920	Dehydratase family	IPR000581	Dihydroxy-acid/6-phosphogluconate dehydratase	34	610	1.1E-221
ProSitePatterns	PS00887	Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2.	IPR020558	Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site	514	525	-
SUPERFAMILY	SSF143975		IPR037237	IlvD/EDD, N-terminal domain	4	425	1.2E-135
Gene3D	G3DSA:3.50.30.80		IPR042096	Dihydroxy-acid dehydratase, C-terminal	426	578	4.0E-55
TIGRFAM	TIGR00110	ilvD: dihydroxy-acid dehydratase	IPR004404	Dihydroxy-acid dehydratase	18	613	7.2E-256
SUPERFAMILY	SSF52016				426	614	1.57E-61
Hamap	MF_00012	Dihydroxy-acid dehydratase [ilvD].	IPR004404	Dihydroxy-acid dehydratase	4	613	44.725

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.