Burkholderia cenocepacia J2315, BCAM0904 (polA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006139 nucleobase-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01612
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00482
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006261 DNA-dependent DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00868
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003676 nucleic acid binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01612
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008408 3'-5' exonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01612
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00482
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG bcj03440 Homologous recombination 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj03420 Nucleotide excision repair 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj03410 Base excision repair 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj00240 Pyrimidine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj03030 DNA replication 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj00230 Purine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF47807 IPR036279 5'-3' exonuclease, C-terminal domain superfamily 174 292 6.73E-28
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 689 712 9.2E-76
Gene3D G3DSA:3.40.50.1010 12 262 2.7E-85
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 780 791 9.2E-76
Gene3D G3DSA:1.10.150.20 177 249 2.7E-85
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 864 877 9.2E-76
Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold IPR020045 DNA polymerase I-like, H3TH domain 174 262 4.2E-23
Gene3D G3DSA:1.10.150.20 698 841 2.2E-108
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 834 850 9.2E-76
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 644 666 9.2E-76
Gene3D G3DSA:3.30.420.10 IPR036397 Ribonuclease H superfamily 317 531 2.6E-66
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 743 768 9.2E-76
Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal 12 173 3.0E-50
CDD cd08637 DNA_pol_A_pol_I_C 537 913 0.0
CDD cd06139 DNA_polA_I_Ecoli_like_exo 335 526 9.22061E-79
Gene3D G3DSA:3.30.70.370 653 913 2.2E-108
Pfam PF01612 3'-5' exonuclease IPR002562 3'-5' exonuclease domain 320 505 8.4E-33
SMART SM00475 IPR002421 5'-3' exonuclease, N-terminal 9 264 1.9E-109
SUPERFAMILY SSF56672 511 917 6.78E-157
SUPERFAMILY SSF53098 IPR012337 Ribonuclease H-like superfamily 323 505 1.92E-52
SUPERFAMILY SSF88723 IPR029060 PIN-like domain superfamily 10 173 1.46E-53
Pfam PF00476 DNA polymerase family A IPR001098 DNA-directed DNA polymerase, family A, palm domain 540 915 1.1E-151
CDD cd09898 H3TH_53EXO IPR020045 DNA polymerase I-like, H3TH domain 176 248 1.03053E-27
Gene3D G3DSA:1.20.1060.10 532 647 2.0E-41
TIGRFAM TIGR00593 pola: DNA polymerase I IPR018320 DNA polymerase 1 12 917 5.0E-272
SMART SM00482 IPR001098 DNA-directed DNA polymerase, family A, palm domain 675 881 2.5E-116
SMART SM00474 IPR002562 3'-5' exonuclease domain 320 506 4.1E-32
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 802 813 9.2E-76
SMART SM00279 IPR008918 Helix-hairpin-helix motif, class 2 176 211 2.4E-12
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 719 732 9.2E-76
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 667 682 9.2E-76
CDD cd09859 PIN_53EXO 14 170 8.70106E-76
ProSitePatterns PS00447 DNA polymerase family A signature. IPR019760 DNA-directed DNA polymerase, family A, conserved site 743 762 -

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.