Burkholderia cenocepacia J2315, BCAL2079 (lpxA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0009245 | lipid A biosynthetic process |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P0A722
|
ECO:0000303 non-traceable author statement used in manual assertion |
15610978 | Reviewed by curator |
| Molecular Function | GO:0008780 | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
Inferred from Sequence Model
Term mapped from: InterPro:cd03351
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0008610 | lipid biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:cd03351
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | bcj00540 | Lipopolysaccharide biosynthesis | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bcj01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG (InterPro) | 00540 | Lipopolysaccharide biosynthesis | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Pfam | PF00132 | Bacterial transferase hexapeptide (six repeats) | IPR001451 | Hexapeptide repeat | 14 | 48 | 1.8E-8 |
| Hamap | MF_00387 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase [lpxA]. | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 1 | 262 | 46.965 |
| SUPERFAMILY | SSF51161 | IPR011004 | Trimeric LpxA-like superfamily | 2 | 262 | 1.23E-77 | |
| TIGRFAM | TIGR01852 | lipid_A_lpxA: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 4 | 260 | 1.5E-103 |
| Pfam | PF00132 | Bacterial transferase hexapeptide (six repeats) | IPR001451 | Hexapeptide repeat | 105 | 136 | 6.3E-9 |
| PIRSF | PIRSF000456 | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 1 | 262 | 1.1E-107 | |
| Gene3D | G3DSA:1.20.1180.10 | IPR037157 | UDP-N-acetylglucosamine O-acyltransferase, C-terminal domain superfamily | 193 | 262 | 6.7E-26 | |
| Pfam | PF13720 | Udp N-acetylglucosamine O-acyltransferase; Domain 2 | IPR029098 | UDP N-acetylglucosamine O-acyltransferase, C-terminal | 176 | 261 | 3.1E-28 |
| Gene3D | G3DSA:2.160.10.10 | 3 | 192 | 7.4E-57 | |||
| CDD | cd03351 | LbH_UDP-GlcNAc_AT | IPR010137 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | 3 | 260 | 8.71733E-151 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.