Burkholderia cenocepacia J2315, BCAL0375 (hemA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00087
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008883 glutamyl-tRNA reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00087
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0033014 tetrapyrrole biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00087
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00087
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc tetrapyrrole biosynthesis I (from glutamate) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj00860 Porphyrin and chlorophyll metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00860 Porphyrin and chlorophyll metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.460.30 IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily 1 163 8.4E-54
SUPERFAMILY SSF69075 IPR036453 Glutamyl tRNA-reductase dimerization domain superfamily 322 422 4.45E-28
Gene3D G3DSA:3.40.50.720 166 317 1.5E-44
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 168 320 3.04E-36
TIGRFAM TIGR01035 hemA: glutamyl-tRNA reductase IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase 4 413 6.1E-126
Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain 325 420 1.1E-26
CDD cd05213 NAD_bind_Glutamyl_tRNA_reduct 3 323 1.10595E-124
ProSitePatterns PS00747 Glutamyl-tRNA reductase signature. IPR018214 Glutamyl-tRNA reductase, conserved site 104 127 -
PIRSF PIRSF000445 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase 1 432 4.8E-153
SUPERFAMILY SSF69742 IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily 1 163 8.5E-46
Pfam PF01488 Shikimate / quinate 5-dehydrogenase IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase 177 310 2.8E-45
Hamap MF_00087 Glutamyl-tRNA reductase [hemA]. IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase 2 419 29.483
Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal 6 161 5.3E-48

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.