Burkholderia cenocepacia J2315, BCAL0317 (hisA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0000105 | histidine biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:MF_01014
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:SSF51366
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003949 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
Inferred from Sequence Model
Term mapped from: InterPro:MF_01014
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | bcj01110 | Biosynthesis of secondary metabolites | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bcj00340 | Histidine metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bcj01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bcj01230 | Biosynthesis of amino acids | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| CDD | cd04732 | HisA | IPR023016 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase | 2 | 239 | 7.6545E-119 |
| Coils | Coil | 234 | 251 | - | |||
| TIGRFAM | TIGR00007 | TIGR00007: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase | IPR006063 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA | 3 | 235 | 2.0E-79 |
| Hamap | MF_01014 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase [hisA]. | IPR023016 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase | 2 | 240 | 36.743 |
| Gene3D | G3DSA:3.20.20.70 | IPR013785 | Aldolase-type TIM barrel | 1 | 242 | 3.7E-89 | |
| Pfam | PF00977 | Histidine biosynthesis protein | IPR006062 | Histidine biosynthesis | 3 | 232 | 5.3E-81 |
| SUPERFAMILY | SSF51366 | IPR011060 | Ribulose-phosphate binding barrel | 1 | 238 | 2.59E-76 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.