Burkholderia thailandensis E264 ATCC 700388, BTH_II2093 (malF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0031177 phosphopantetheine binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00823
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.47.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.70.3050 625 695 7.2E-204
SMART SM00826 IPR020807 Polyketide synthase, dehydratase domain 718 955 1.1E-5
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 1989 2060 3.5E-15
SMART SM00825 Beta-ketoacyl synthase IPR020841 Polyketide synthase, beta-ketoacyl synthase domain 136 559 5.4E-188
TIGRFAM TIGR01746 Thioester-redct: thioester reductase domain IPR010080 Thioester reductase-like domain 3657 4021 3.5E-76
MobiDBLite mobidb-lite consensus disorder prediction 116 130 -
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 1974 2063 8.2E-22
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 3548 3621 1.7E-16
SUPERFAMILY SSF52777 3042 3277 3.0E-51
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 1983 2060 13.718
SMART SM01294 1990 2056 1.2E-4
Gene3D G3DSA:3.40.50.720 1070 1512 7.7E-79
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1080 1267 7.87E-16
Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain IPR014031 Beta-ketoacyl synthase, C-terminal 379 504 7.7E-41
Gene3D G3DSA:3.40.50.720 3640 4026 6.8E-86
ProSitePatterns PS00012 Phosphopantetheine attachment site. IPR006162 Phosphopantetheine attachment site 2015 2030 -
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 3657 3970 1.48E-40
Pfam PF16197 Ketoacyl-synthetase C-terminal extension IPR032821 Ketoacyl-synthetase, C-terminal extension 508 616 7.9E-15
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 15 86 1.6E-7
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 3541 3627 2.5E-22
CDD cd05235 SDR_e1 IPR010080 Thioester reductase-like domain 3658 3914 3.72035E-73
MobiDBLite mobidb-lite consensus disorder prediction 793 807 -
Pfam PF07993 Male sterility protein IPR013120 Male sterility, NAD-binding 3659 3897 2.1E-55
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 5 86 8.695
Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain IPR014031 Beta-ketoacyl synthase, C-terminal 2372 2488 2.4E-38
Gene3D G3DSA:3.30.559.10 IPR023213 Chloramphenicol acetyltransferase-like domain superfamily 2861 3223 8.5E-108
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 2755 2817 1.6E-9
Gene3D G3DSA:3.30.70.3290 2554 2693 8.5E-235
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 1 87 9.3E-15
CDD cd02440 AdoMet_MTases 1752 1857 1.53516E-5
MobiDBLite mobidb-lite consensus disorder prediction 2824 2855 -
SUPERFAMILY SSF53335 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase 1684 1909 3.02E-24
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 17 82 8.0E-7
Pfam PF00668 Condensation domain IPR001242 Condensation domain 2859 3281 1.1E-66
CDD cd00833 PKS 2133 2539 0.0
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 2746 2838 1.31E-13
CDD cd00833 PKS 135 554 0.0
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 2752 2821 2.6E-6
Pfam PF08659 KR domain IPR013968 Polyketide synthase, ketoreductase domain 1282 1460 2.0E-36
Gene3D G3DSA:3.40.47.10 IPR016039 Thiolase-like 2131 2709 8.5E-235
CDD cd08953 KR_2_SDR_x 1169 1502 4.71749E-73
Pfam PF16197 Ketoacyl-synthetase C-terminal extension IPR032821 Ketoacyl-synthetase, C-terminal extension 2491 2601 1.9E-12
SUPERFAMILY SSF53901 IPR016039 Thiolase-like 131 554 9.71E-86
Gene3D G3DSA:3.40.50.150 1712 1914 2.6E-47
Gene3D G3DSA:1.10.1200.10 IPR036736 ACP-like superfamily 2740 2820 2.1E-14
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 3550 3625 16.516
Gene3D G3DSA:3.40.47.10 IPR016039 Thiolase-like 136 715 7.2E-204
SUPERFAMILY SSF53901 IPR016039 Thiolase-like 2126 2540 2.03E-85
SUPERFAMILY SSF52777 2861 3035 2.78E-33
Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain IPR014030 Beta-ketoacyl synthase, N-terminal 2130 2363 9.2E-81
MobiDBLite mobidb-lite consensus disorder prediction 778 829 -
Gene3D G3DSA:3.30.559.30 3039 3278 8.5E-108
SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1282 1462 6.0E-28
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 7 86 8.38E-13
Pfam PF14765 Polyketide synthase dehydratase IPR020807 Polyketide synthase, dehydratase domain 837 1068 4.9E-24
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1277 1518 3.78E-31
Pfam PF08242 Methyltransferase domain IPR013217 Methyltransferase type 12 1752 1855 6.8E-14
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 1990 2055 6.1E-15
Pfam PF00550 Phosphopantetheine attachment site IPR009081 Phosphopantetheine binding ACP domain 3559 3620 3.7E-11
ProSitePatterns PS00606 Beta-ketoacyl synthases active site. IPR018201 Beta-ketoacyl synthase, active site 2276 2292 -
SMART SM00823 Phosphopantetheine attachment site IPR020806 Polyketide synthase, phosphopantetheine-binding domain 3556 3625 8.6E-5
SUPERFAMILY SSF47336 IPR036736 ACP-like superfamily 1987 2142 7.98E-15
SMART SM00825 Beta-ketoacyl synthase IPR020841 Polyketide synthase, beta-ketoacyl synthase domain 2131 2544 8.4E-184
Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain IPR014030 Beta-ketoacyl synthase, N-terminal 135 371 7.2E-81
ProSitePatterns PS00606 Beta-ketoacyl synthases active site. IPR018201 Beta-ketoacyl synthase, active site 284 300 -
MobiDBLite mobidb-lite consensus disorder prediction 99 130 -
ProSiteProfiles PS50075 Carrier protein (CP) domain profile. IPR009081 Phosphopantetheine binding ACP domain 2746 2821 13.893

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.