Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSS1542
|
Name |
bsaR
|
Replicon | chromosome 2 |
Genomic location | 2095059 - 2095466 (- strand) |
Comment | This gene is part of the type III secretion system T3SS-3 (bsa) gene locus. BsaR is homologous to the Salmonella chaperone InvB which has been shown to be required for secretion of the effector proteins SopE and SopA (PMID:14645290). BsaR has been predicted to be the chaperone for BopE using a computational screen for chaperones in B. pseudomallei K96243 (PMID:16164564) but this has not been validated yet. |
RefSeq | YP_111548.1 |
GI | 53722563 |
Entrez | 3096685 |
GI | 53722563 |
INSDC | CAH39015.1 |
NCBI Locus Tag | BPSS1542 |
RefSeq | YP_111548.1,GeneID |
UniParc | UPI000043BD28 |
UniProtKB Acc | Q63K24 |
UniProtKB ID | Q63K24_BURPS |
UniRef100 | UniRef100_A0A069BE17 |
UniRef50 | UniRef50_Q2T721 |
UniRef90 | UniRef90_Q2T721 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
chaperone protein BsaR (T3SS-3)
|
Synonyms |
surface presentation of antigens protein |
Evidence for Translation |
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (14.1 kDa, pI 4.49, PMID:21960737)
|
Charge (pH 7) | -10.23 |
Kyte-Doolittle Hydrophobicity Value | 0.182 |
Molecular Weight (kDa) | 14837.8 |
Isoelectric Point (pI) | 4.36 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | VFDB : VF0428 |
Category | T3SS-3 |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | |
Notes | |
Reference | 17984080 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 11 genera
|
Burkholderia Ortholog Group |
BG019846 (320 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSS1542
Search term: bsaR
Search term: chaperone protein BsaR (T3SS-3)
|
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
|
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
|
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
|
A genome-wide screen identifies a Bordetella type III secretion effector and candidate effectors in other species.
Panina EM, Mattoo S, Griffith N, Kozak NA, Yuk MH, Miller JF
Mol Microbiol 2005 Oct;58(1):267-79
PubMed ID: 16164564
|
InvB is a type III secretion-associated chaperone for the Salmonella enterica effector protein SopE.
Lee SH, Galán JE
J Bacteriol 2003 Dec;185(24):7279-84
PubMed ID: 14645290
|