Burkholderia pseudomallei K96243, BPSL2896 (purH)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0003937	IMP cyclohydrolase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01808	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF53927	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01808	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006164	purine nucleotide biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01808	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
MetaCyc		inosine-5'-phosphate biosynthesis I	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		inosine-5'-phosphate biosynthesis II	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bps01110	Biosynthesis of secondary metabolites	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG (InterPro)	00230	Purine metabolism	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG (InterPro)	00670	One carbon pool by folate	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bps01130	Biosynthesis of antibiotics	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bps00670	One carbon pool by folate	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bps01100	Metabolic pathways	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		inosine-5'-phosphate biosynthesis III	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bps00230	Purine metabolism	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
ProSiteProfiles	PS51855	MGS-like domain profile.			1	145	24.039
Pfam	PF02142	MGS-like domain	IPR011607	Methylglyoxal synthase-like domain	14	129	2.2E-30
Hamap	MF_00139	Bifunctional purine biosynthesis protein PurH [purH].	IPR002695	Bifunctional purine biosynthesis protein PurH-like	2	521	45.368
SUPERFAMILY	SSF52335		IPR036914	Methylglyoxal synthase-like domain superfamily	2	193	3.92E-73
Pfam	PF01808	AICARFT/IMPCHase bienzyme	IPR002695	Bifunctional purine biosynthesis protein PurH-like	134	451	5.5E-120
CDD	cd01421	IMPCH			3	191	1.35451E-117
Gene3D	G3DSA:3.40.140.20		IPR024051	AICAR transformylase, duplicated domain superfamily	212	365	7.1E-60
SMART	SM00851		IPR011607	Methylglyoxal synthase-like domain	14	129	9.3E-66
PIRSF	PIRSF000414		IPR002695	Bifunctional purine biosynthesis protein PurH-like	1	521	3.4E-221
TIGRFAM	TIGR00355	purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	IPR002695	Bifunctional purine biosynthesis protein PurH-like	3	521	1.3E-227
Gene3D	G3DSA:3.40.50.1380		IPR036914	Methylglyoxal synthase-like domain superfamily	1	196	5.6E-90
SMART	SM00798		IPR002695	Bifunctional purine biosynthesis protein PurH-like	134	453	3.8E-206
Gene3D	G3DSA:3.40.140.20		IPR024051	AICAR transformylase, duplicated domain superfamily	384	521	2.0E-56
SUPERFAMILY	SSF53927		IPR016193	Cytidine deaminase-like	215	521	4.21E-126

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.