Burkholderia cenocepacia AU 1054, BCEN_RS10945

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS50991
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00815
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009098 leucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00572
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003852 2-isopropylmalate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00572
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019752 carboxylic acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00815
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc 3-methylbutanol biosynthesis (engineered) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00620 Pyruvate metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00290 Valine, leucine and isoleucine biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.160.270 375 537 1.2E-23
TIGRFAM TIGR00970 leuA_yeast: 2-isopropylmalate synthase IPR005668 2-isopropylmalate synthase 5 439 1.5E-212
Gene3D G3DSA:3.20.20.70 IPR013785 Aldolase-type TIM barrel 9 374 4.4E-155
SUPERFAMILY SSF89000 387 436 3.14E-8
SMART SM00917 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 420 538 8.1E-4
ProSiteProfiles PS50991 Pyruvate carboxyltransferase domain. IPR000891 Pyruvate carboxyltransferase 31 305 17.962
SUPERFAMILY SSF51569 20 328 2.93E-98
Pfam PF00682 HMGL-like IPR000891 Pyruvate carboxyltransferase 32 311 9.2E-74
ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site 38 54 -
Hamap MF_00572 2-isopropylmalate synthase [leuA]. IPR005668 2-isopropylmalate synthase 6 539 49.396
CDD cd07942 DRE_TIM_LeuA IPR039371 LeuA, N-terminal catalytic TIM barrel domain 30 313 0.0
ProSitePatterns PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site 241 254 -
SUPERFAMILY SSF110921 IPR036230 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily 493 536 4.84E-5

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.