Burkholderia vietnamiensis G4, Bcep1808_4202 (bceC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia vietnamiensis G4
GCF_000016205.1|latest
Locus Tag
Bcep1808_4202
NCBI Locus TagBCEP1808_RS21015
Name
bceC
Replicon chromosome 2
Genomic location 1009905 - 1011320 (+ strand)

Cross-References

RefSeq WP_011881534.1
GI 134292911
Entrez 4950419
GI 134292911
INSDC ABO57182.1
NCBI Locus Tag BCEP1808_RS21015
NCBI Old Locus Tag Bcep1808_4202
RefSeq WP_011881534.1
UniParc UPI00003A5280
UniProtKB Acc A4JLM9
UniProtKB ID A4JLM9_BURVG
UniRef100 UniRef100_A4JLM9
UniRef50 UniRef50_O86422
UniRef90 UniRef90_B4EMQ8

Product

Feature Type CDS
Coding Frame 1
Product Name
BceC
Product Name Confidence: Class 2
Synonyms UDP-glucose 6-dehydrogenase
Evidence for Translation
Charge (pH 7) -8.20
Kyte-Doolittle Hydrophobicity Value -0.172
Molecular Weight (kDa) 51356.6
Isoelectric Point (pI) 5.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y0D OXIDOREDUCTASE 12/02/10 BceC mutation Y10K BURKHOLDERIA CEPACIA 2.8 X-RAY DIFFRACTION 95.8
2Y0E OXIDOREDUCTASE 12/02/10 BceC and the final step of UGDs reaction BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 96.0
2Y0C OXIDOREDUCTASE 12/02/10 BceC mutation Y10S BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 95.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000893 (1284 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcep1808_4202
Search term: bceC
Search term: BceC

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 9.3e-65
Percent Identity: 36.0
Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 9.3e-65
Percent Identity: 36.0

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863