Strain |
Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest |
Locus Tag |
BTH_II0868
|
NCBI Locus Tag | BTH_RS04505 |
Name |
hcp-5
|
Replicon | chromosome II |
Genomic location | 1018597 - 1019085 (- strand) |
Transposon Mutants | 3 transposon mutants in E264 ATCC 700388 |
Comment | This gene is part of cluster known as the type VI secretion system gene cluster tss-5 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170). While other T6SSs were dispensible, T6SS-5 is required for virulence in a murine acute melioidosis model (PMID:20865170). |
RefSeq | YP_439065.1 |
GI | 83716550 |
Entrez | 3845504 |
GI | 83716550 |
INSDC | AIP28033.1 |
NCBI Locus Tag | BTH_RS04505 |
NCBI Old Locus Tag | BTH_II0868 |
RefSeq | WP_009896195.1 |
UniParc | UPI0000667454 |
UniProtKB Acc | Q2T6Y4 |
UniProtKB ID | Q2T6Y4_BURTA |
UniRef100 | UniRef100_Q2T6Y4 |
UniRef50 | UniRef50_Q2T6Y4 |
UniRef90 | UniRef90_Q2T6Y4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type VI secretion system protein TssD-5
|
Synonyms |
Hcp-5 hcp protein |
Evidence for Translation | |
Charge (pH 7) | -3.90 |
Kyte-Doolittle Hydrophobicity Value | -0.450 |
Molecular Weight (kDa) | 18221.7 |
Isoelectric Point (pI) | 5.62 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | VFDB : VF0429 |
Category | T6SS-1 |
Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
Host Organism | |
Notes | |
Annotation transferred from | Burkholderia pseudomallei K96243 |
Reference | 17984080 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 73 genera
|
Burkholderia Ortholog Group |
BG019360 (317 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BTH_II0868
Search term: hcp-5
Search term: type VI secretion system protein TssD-5
|
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
|
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
|
The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.
Burtnick MN, Brett PJ, Harding SV, Ngugi SA, Ribot WJ, Chantratita N, Scorpio A, Milne TS, Dean RE, Fritz DL, Peacock SJ, Prior JL, Atkins TP, Deshazer D
Infect Immun 2011 Apr;79(4):1512-25
PubMed ID: 21300775
|
BPSS1504, a cluster 1 type VI secretion gene, is involved in intracellular survival and virulence of Burkholderia pseudomallei.
Hopf V, Göhler A, Eske-Pogodda K, Bast A, Steinmetz I, Breitbach K
Infect Immun 2014 May;82(5):2006-15
PubMed ID: 24595140
|
Regulation of type VI secretion system during Burkholderia pseudomallei infection.
Chen Y, Wong J, Sun GW, Liu Y, Tan GY, Gan YH
Infect Immun 2011 Aug;79(8):3064-73
PubMed ID: 21670170
|
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
|
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434
|