Burkholderia cenocepacia J2315, BCAL1700 (orbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL1700
NCBI Locus TagQU43_RS45020
Name
orbA
Replicon chromosome 1
Genomic location 1872619 - 1874886 (+ strand)

Cross-References

RefSeq WP_006486047.1
GI 206560062
Entrez 6934011
GI 206560062
INSDC CAR51998.1
NCBI Locus Tag QU43_RS45020
NCBI Old Locus Tag BCAL1700
RefSeq WP_006486047.1,GeneID
UniParc UPI00000B9C59
UniProtKB Acc B4E998
UniProtKB ID B4E998_BURCJ
UniRef100 UniRef100_B4E998
UniRef50 UniRef50_B4E998
UniRef90 UniRef90_B4E998

Product

Feature Type CDS
Coding Frame 1
Product Name
ornibactin receptor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.62
Kyte-Doolittle Hydrophobicity Value -0.334
Molecular Weight (kDa) 81705.5
Isoelectric Point (pI) 8.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Outer Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Siderophore biosynthesis and uptake (ornibactin)
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes BCAL1700 mutant is attenuated for virulence in rat chronic respiratory infection model
Reference 11083764

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 261 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001463 (2439 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1700
Search term: orbA

References

Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding L-ornithine N(5)-oxygenase.
Sokol PA(1), Darling P, Woods DE, Mahenthiralingam E, Kooi C.
Infect Immun. 1999 Sep;67(9):4443-55.
PubMed ID: 10456885
Identification of a siderophore receptor required for ferric ornibactin uptake in Burkholderia cepacia.
Sokol PA, Darling P, Lewenza S, Corbett CR, Kooi CD.
Infect Immun. 2000 Dec;68(12):6554-60.
PubMed ID: 11083764
Identification of a siderophore receptor required for ferric ornibactin uptake in Burkholderia cepacia.
Sokol PA, Darling P, Lewenza S, Corbett CR, Kooi CD.
Infect Immun. 2000 Dec;68(12):6554-60.
PubMed ID: 11083764