Burkholderia cenocepacia J2315, BCAM2132 (nbaE)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2132
NCBI Locus Tag	QU43_RS65025
Name	nbaE
Replicon	chromosome 2
Genomic location	2369712 - 2371202 (- strand)

Cross-References

RefSeq	WP_006490292.1
GI	206563969
Entrez	6930564
GI	206563969
INSDC	CAR55990.1
NCBI Locus Tag	QU43_RS65025
NCBI Old Locus Tag	BCAM2132
RefSeq	WP_006490292.1,GeneID
UniParc	UPI00017BA190
UniProtKB Acc	B4EFS9
UniProtKB ID	B4EFS9_BURCJ
UniRef100	UniRef100_B4EFS9
UniRef50	UniRef50_P23105
UniRef90	UniRef90_B4EFS9

Product

Feature Type	CDS
Coding Frame	1
Product Name	2-aminomuconate 6-semialdehyde dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.30
Kyte-Doolittle Hydrophobicity Value	-0.016
Molecular Weight (kDa)	53237.7
Isoelectric Point (pI)	5.95

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4U3W	OXIDOREDUCTASE	07/23/14	X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from Burkholderia cenocepacia	BURKHOLDERIA CENOCEPACIA	1.9501	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG006676 (79 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2132 Search term: nbaE Search term: 2-aminomuconate 6-semialdehyde dehydrogenase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000265605 aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] E-value: 2.4e-111 Percent Identity: 41.0

References