Burkholderia cenocepacia J2315, BCAL2015 (ispF)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2015
NCBI Locus Tag	QU43_RS46635
Name	ispF
Replicon	chromosome 1
Genomic location	2222541 - 2223026 (- strand)

Cross-References

RefSeq	WP_006488015.1
GI	206560378
Entrez	6932187
GI	206560378
INSDC	CAR52315.1
NCBI Locus Tag	QU43_RS46635
NCBI Old Locus Tag	BCAL2015
RefSeq	WP_006488015.1,GeneID
UniParc	UPI0000D7ECDC
UniProtKB Acc	B4EC22
UniProtKB ID	ISPF_BURCJ
UniRef100	UniRef100_Q1BHA4
UniRef50	UniRef50_Q8EBR3
UniRef90	UniRef90_Q13Z30

Product

Feature Type	CDS
Coding Frame	1
Product Name	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.84
Kyte-Doolittle Hydrophobicity Value	0.065
Molecular Weight (kDa)	16923.2
Isoelectric Point (pI)	6.68

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4C8E	LYASE	09/30/13	IspF (Burkholderia cenocepacia) 2CMP complex	BURKHOLDERIA CENOCEPACIA	1.9	X-RAY DIFFRACTION	99.4
4C8I	LYASE	10/01/13	IspF (Burkholderia cenocepacia) citrate complex	BURKHOLDERIA CENOCEPACIA	2.0	X-RAY DIFFRACTION	99.4
4C8G	LYASE	10/01/13	IspF (Burkholderia cenocepacia) CMP complex	BURKHOLDERIA CENOCEPACIA	2.0	X-RAY DIFFRACTION	99.4

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 520 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001805 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2015 Search term: ispF Search term: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Human Homologs

References