Strain |
Burkholderia dolosa AU0158 (complete genome)
GCF_000959505.1|latest |
Locus Tag |
AK34_RS09175
|
NCBI Old Locus Tag | AK34_4994 |
Name |
Synonym: PaaZ-ECH Synonym: BDAG_04127 |
Replicon | chromosome 2 |
Genomic location | 2102525 - 2102983 (- strand) |
Comment | In E. coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH. |
RefSeq | WP_035974808.1 |
GI | 738013427 |
NCBI Locus Tag | AK34_RS09175 |
NCBI Old Locus Tag | AK34_4994 |
RefSeq | WP_035974808.1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
putative (R)-specific oxepin-CoA hydratase
|
Synonyms |
acyl dehydratase |
Evidence for Translation | |
Charge (pH 7) | -0.63 |
Kyte-Doolittle Hydrophobicity Value | -0.159 |
Molecular Weight (kDa) | 16894.2 |
Isoelectric Point (pI) | 6.79 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Results | Analysis not done |
Burkholderia Ortholog Group |
BG005317 (313 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: AK34_RS09175
Search term: putative (R)-specific oxepin-CoA hydratase
|
Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point.
Teufel R, Gantert C, Voss M, Eisenreich W, Haehnel W, Fuchs G
J Biol Chem 2011 Apr 1;286(13):11021-34
PubMed ID: 21296885
|