Burkholderia cenocepacia J2315, BCAS0225 (shvR)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS69805
Replicon chromosome 3
Genomic location 243574 - 244566 (+ strand)


RefSeq WP_006482230.1
GI 197295074
Entrez 6804596
GI 197295074
INSDC CAR57157.1
NCBI Locus Tag QU43_RS69805
NCBI Old Locus Tag BCAS0225
RefSeq WP_006482230.1,GeneID
UniParc UPI00017BB251
UniProtKB Acc B4EPZ1
UniRef100 UniRef100_B4EPZ1
UniRef50 UniRef50_B1KBK8
UniRef90 UniRef90_B1KBK8


Feature Type CDS
Coding Frame 1
Product Name
LysR family regulatory protein
Product Name Confidence: Class 1
Synonyms shiny variant regulator, ShvR
Evidence for Translation
Charge (pH 7) 2.49
Kyte-Doolittle Hydrophobicity Value -0.062
Molecular Weight (kDa) 36469.3
Isoelectric Point (pI) 7.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category ShvR regulator
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Medicago sativa
Notes shvR in K56-2 is avirulent in alfalfa seedling model of infection.
Reference 17967860

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 472 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005276 (86 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0225
Search term: shvR

Human Homologs


Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
BMC Genomics 2009 Sep 17;10:441
PubMed ID: 19761612
The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes.
O'Grady EP, Nguyen DT, Weisskopf L, Eberl L, Sokol PA
J Bacteriol 2011 Jan;193(1):163-76
PubMed ID: 20971902
A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence.
Bernier SP, Nguyen DT, Sokol PA
Infect Immun 2008 Jan;76(1):38-47
PubMed ID: 17967860
The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection.
Gomes MC, Tasrini Y, Subramoni S, Agnoli K, Feliciano JR, Eberl L, Sokol P, O'Callaghan D, Vergunst AC
PLoS Pathog 2018 Dec;14(12):e1007473
PubMed ID: 30513124