Burkholderia cenocepacia J2315, BCAS0225 (shvR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAS0225
NCBI Locus TagQU43_RS69805
Name
shvR
Replicon chromosome 3
Genomic location 243574 - 244566 (+ strand)

Cross-References

RefSeq WP_006482230.1
GI 197295074
Entrez 6804596
GI 197295074
INSDC CAR57157.1
NCBI Locus Tag QU43_RS69805
NCBI Old Locus Tag BCAS0225
RefSeq WP_006482230.1,GeneID
UniParc UPI00017BB251
UniProtKB Acc B4EPZ1
UniProtKB ID B4EPZ1_BURCJ
UniRef100 UniRef100_B4EPZ1
UniRef50 UniRef50_B1KBK8
UniRef90 UniRef90_B1KBK8

Product

Feature Type CDS
Coding Frame 1
Product Name
LysR family regulatory protein
Product Name Confidence: Class 1
Synonyms shiny variant regulator, ShvR
Evidence for Translation
Charge (pH 7) 2.49
Kyte-Doolittle Hydrophobicity Value -0.062
Molecular Weight (kDa) 36469.3
Isoelectric Point (pI) 7.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category ShvR regulator
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Medicago sativa
Notes shvR in K56-2 is avirulent in alfalfa seedling model of infection.
Reference 17967860

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 472 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005276 (86 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0225
Search term: shvR

References

Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
BMC Genomics 2009 Sep 17;10:441
PubMed ID: 19761612
The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes.
O'Grady EP, Nguyen DT, Weisskopf L, Eberl L, Sokol PA
J Bacteriol 2011 Jan;193(1):163-76
PubMed ID: 20971902
A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence.
Bernier SP, Nguyen DT, Sokol PA
Infect Immun 2008 Jan;76(1):38-47
PubMed ID: 17967860
The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection.
Gomes MC, Tasrini Y, Subramoni S, Agnoli K, Feliciano JR, Eberl L, Sokol P, O'Callaghan D, Vergunst AC
PLoS Pathog 2018 Dec;14(12):e1007473
PubMed ID: 30513124