Burkholderia cenocepacia J2315, BCAS0222 (afcA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAS0222
NCBI Locus TagQU43_RS69790
Name
afcA
Replicon chromosome 3
Genomic location 238980 - 240743 (- strand)

Cross-References

RefSeq YP_002153612.1
GI 197295071
Entrez 6804595
GI 197295071
NCBI Locus Tag QU43_RS69790
NCBI Old Locus Tag BCAS0222
RefSeq YP_002153612.1

Product

Feature Type CDS
Coding Frame 1
Product Name
putative AMP-dependent synthetase
Product Name Confidence: Class 1
Synonyms putative amino acid activating protein
Evidence for Translation
Charge (pH 7) -6.23
Kyte-Doolittle Hydrophobicity Value 0.059
Molecular Weight (kDa) 62442.4
Isoelectric Point (pI) 6.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 575 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001460 (2297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0222
Search term: afcA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 4.9e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 4.9e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 4.9e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 4.9e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 4.9e-07
Percent Identity: 44.3

References

Characterization of genes involved in biosynthesis of a novel antibiotic from Burkholderia cepacia BC11 and their role in biological control of Rhizoctonia solani.
Kang Y, Carlson R, Tharpe W, Schell MA
Appl Environ Microbiol 1998 Oct;64(10):3939-47
PubMed ID: 9758823