Burkholderia cenocepacia J2315, BCAS0156 (ampC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAS0156
NCBI Locus TagQU43_RS69450
Name
ampC
Replicon chromosome 3
Genomic location 174406 - 175575 (+ strand)

Cross-References

RefSeq WP_006485212.1
GI 197295007
Entrez 6804729
GI 197295007
INSDC CAR57088.1
NCBI Locus Tag QU43_RS69450
NCBI Old Locus Tag BCAS0156
RefSeq WP_006485212.1,GeneID
UniParc UPI00017BB1D6
UniProtKB Acc B4EPS2
UniProtKB ID B4EPS2_BURCJ
UniRef100 UniRef100_B4EPS2
UniRef50 UniRef50_P85302
UniRef90 UniRef90_A0A071M3A1

Product

Feature Type CDS
Coding Frame 1
Product Name
beta-lactamase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 9.40
Kyte-Doolittle Hydrophobicity Value -0.030
Molecular Weight (kDa) 41857.0
Isoelectric Point (pI) 9.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5E2G HYDROLASE 10/01/15 Crystal Structure of D-alanine Carboxypeptidase AmpC from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA 1.651 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 319 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005235 (327 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0156
Search term: ampC
Search term: beta-lactamase

Human Homologs

References

Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC beta-lactamase of a Serratia marcescens clinical isolate.
Mammeri H, Poirel L, Bemer P, Drugeon H, Nordmann P
Antimicrob Agents Chemother 2004 Mar;48(3):716-20
PubMed ID: 14982755
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103