Burkholderia cenocepacia J2315, BCAM2758 (cblS)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS68250
Replicon chromosome 2
Genomic location 3119001 - 3121154 (- strand)


RefSeq WP_006485049.1
GI 206564596
Entrez 6930413
GI 206564596
INSDC CAR56622.1
NCBI Locus Tag QU43_RS68250
NCBI Old Locus Tag BCAM2758
RefSeq WP_006485049.1,GeneID
UniParc UPI0000004B27
UniProtKB Acc B4ELF7
UniRef100 UniRef100_B4ELF7
UniRef50 UniRef50_B2UH73
UniRef90 UniRef90_B4ELF7


Feature Type CDS
Coding Frame 1
Product Name
two-component regulatory system sensor kinase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 7.14
Kyte-Doolittle Hydrophobicity Value 0.138
Molecular Weight (kDa) 77639.8
Isoelectric Point (pI) 8.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Cable pili
Evidence ECO:0000354
gene neighbors evidence used in manual assertion
Host Organism Homo sapiens
Notes Cable pili are necessary for inducing A549 transformed human epithelial lung cell death via apoptosis
Reference 17537663

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005922 (40 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2758
Search term: cblS

Human Homologs


The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Sun L, Jiang RZ, Steinbach S, Holmes A, Campanelli C, Forstner J, Sajjan U, Tan Y, Riley M, Goldstein R
Nat Med 1995 Jul;1(7):661-6
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US
Infect Immun 2005 Sep;73(9):5426-37
PubMed ID: 16113259
Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia.
Sajjan US, Xie H, Lefebre MD, Valvano MA, Forstner JF
Microbiology 2003 Apr;149(Pt 4):961-971
PubMed ID: 12686638
Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia.
Tomich M, Mohr CD
J Bacteriol 2004 Jun;186(12):3826-36
PubMed ID: 15175296