Burkholderia cenocepacia J2315, BCAM2630 (hmuV)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2630
NCBI Locus TagQU43_RS67605
Name
hmuV
Synonym: phuV
Replicon chromosome 2
Genomic location 2979794 - 2980615 (+ strand)

Cross-References

RefSeq WP_006485871.1
GI 206564468
Entrez 6930500
GI 206564468
INSDC CAR56494.1
NCBI Locus Tag QU43_RS67605
NCBI Old Locus Tag BCAM2630
RefSeq WP_006485871.1,GeneID
UniParc UPI00017BA44D
UniProtKB Acc B4EKB5
UniProtKB ID B4EKB5_BURCJ
UniRef100 UniRef100_B4EKB5
UniRef50 UniRef50_Q1BJA5
UniRef90 UniRef90_Q1BJA5

Product

Feature Type CDS
Coding Frame 1
Product Name
hemin importer ATP-binding subunit
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.06
Kyte-Doolittle Hydrophobicity Value 0.007
Molecular Weight (kDa) 29191.1
Isoelectric Point (pI) 7.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5B58 METAL BINDING PROTEIN 04/25/16 Inward-facing conformation of ABC heme importer BhuUV in complex with periplasmic heme binding protein BhuT from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA J2315 3.21 X-RAY DIFFRACTION 100.0
5B57 METAL TRANSPORT 04/25/16 Inward-facing conformation of ABC heme importer BhuUV from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA J2315 2.8 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 668 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004246 (596 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2630
Search term: hmuV

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 5.5e-09
Percent Identity: 27.3
Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 5.5e-09
Percent Identity: 27.3
Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 5.5e-09
Percent Identity: 27.3

References

Identification of potential CepR regulated genes using a cep box motif-based search of the Burkholderia cenocepacia genome.
Chambers CE, Lutter EI, Visser MB, Law PP, Sokol PA
BMC Microbiol 2006 Dec 22;6:104
PubMed ID: 17187664