Burkholderia cenocepacia J2315, BCAM2550 (ceoB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2550
NCBI Locus TagQU43_RS67210
Name
ceoB
Replicon chromosome 2
Genomic location 2892767 - 2895967 (- strand)
CommentMember of ceoAB-opcM (rnd-10) operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump (RND-10)
Comment Major substrates of RND-10 are chloramphenicol, flouroquinolones and trimethoprim

Cross-References

RefSeq WP_006484500.1
GI 206564391
Entrez 6930570
GI 206564391
INSDC CAR56416.1
NCBI Locus Tag QU43_RS67210
NCBI Old Locus Tag BCAM2550
RefSeq WP_006484500.1,GeneID
UniParc UPI00017BA3F4
UniProtKB Acc B4EJQ0
UniProtKB ID B4EJQ0_BURCJ
UniRef100 UniRef100_B4EJQ0
UniRef50 UniRef50_Q8EBL9
UniRef90 UniRef90_B4EJQ0

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug efflux system transporter protein CeoB
Product Name Confidence: Class 1
Synonyms RND-10 efflux system transporter protein
Evidence for Translation
Charge (pH 7) 4.44
Kyte-Doolittle Hydrophobicity Value 0.310
Molecular Weight (kDa) 114773.5
Isoelectric Point (pI) 8.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001444 (2569 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2550
Search term: ceoB

References

Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia).
Nair BM, Cheung KJ Jr, Griffith A, Burns JL
J Clin Invest 2004 Feb;113(3):464-73
PubMed ID: 14755343
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825