Burkholderia cenocepacia J2315, BCAM2449

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2449
NCBI Locus TagQU43_RS66675
Name
Replicon chromosome 2
Genomic location 2767647 - 2768381 (+ strand)
CommentMember of ceoAB-opcM (rnd-10) operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump (RND-10)
Comment Major substrates of RND-10 are chloramphenicol, flouroquinolones and trimethoprim

Cross-References

RefSeq WP_006490078.1
GI 206564289
Entrez 6929999
GI 206564289
INSDC CAR56314.1
NCBI Locus Tag QU43_RS66675
NCBI Old Locus Tag BCAM2449
RefSeq WP_006490078.1,GeneID
UniParc UPI00017BA342
UniProtKB Acc B4EIL5
UniProtKB ID B4EIL5_BURCJ
UniRef100 UniRef100_U1ZJW1
UniRef50 UniRef50_C9Y1T6
UniRef90 UniRef90_A0B2V9

Product

Feature Type CDS
Coding Frame 1
Product Name
putative metallophosphoesterase
Product Name Confidence: Class 1
Synonyms RND-10 efflux system outer membrane protein
Evidence for Translation
Charge (pH 7) -9.20
Kyte-Doolittle Hydrophobicity Value -0.210
Molecular Weight (kDa) 26467.4
Isoelectric Point (pI) 5.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 225 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004112 (223 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2449

References

Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia).
Nair BM, Cheung KJ Jr, Griffith A, Burns JL
J Clin Invest 2004 Feb;113(3):464-73
PubMed ID: 14755343
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825