Burkholderia cenocepacia J2315, BCAM2165 (penB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2165
NCBI Locus TagQU43_RS65190
Name
penB
Replicon chromosome 2
Genomic location 2413082 - 2414020 (- strand)

Cross-References

RefSeq WP_012493495.1
GI 206564002
Entrez 6929758
GI 206564002
INSDC CAR56023.1
NCBI Locus Tag QU43_RS65190
NCBI Old Locus Tag BCAM2165
RefSeq WP_012493495.1,GeneID
UniParc UPI00017B9F53
UniProtKB Acc B4EFW2
UniProtKB ID B4EFW2_BURCJ
UniRef100 UniRef100_B4EFW2
UniRef50 UniRef50_Q8GD10
UniRef90 UniRef90_B4EFW2

Product

Feature Type CDS
Coding Frame 1
Product Name
putative beta-lactamase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.35
Kyte-Doolittle Hydrophobicity Value 0.077
Molecular Weight (kDa) 32347.4
Isoelectric Point (pI) 8.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 144 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003909 (644 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2165
Search term: penB

References

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.
Poirel L, Rodriguez-Martinez JM, Plésiat P, Nordmann P
Antimicrob Agents Chemother 2009 Mar;53(3):876-82
PubMed ID: 19075063
Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator.
Trépanier S, Prince A, Huletsky A
Antimicrob Agents Chemother 1997 Nov;41(11):2399-405
PubMed ID: 9371340
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cell Wall Recycling-Linked Coregulation of AmpC and PenB β-Lactamases through ampD Mutations in Burkholderia cenocepacia.
Hwang J, Kim HS
Antimicrob Agents Chemother 2015 Dec;59(12):7602-10
PubMed ID: 26416862