Burkholderia cenocepacia J2315, BCAM1947 (oqxA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1947
NCBI Locus TagQU43_RS64080
Name
oqxA
Replicon chromosome 2
Genomic location 2163707 - 2164903 (- strand)
CommentMember of rnd-9 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-9
Comment Major RND-9 substrate is tobramycin, chlorhexidine (in biofilm grown cells)

Cross-References

RefSeq WP_006485134.1
GI 206563792
Entrez 6929578
GI 206563792
INSDC CAR55806.1
NCBI Locus Tag QU43_RS64080
NCBI Old Locus Tag BCAM1947
RefSeq WP_006485134.1,GeneID
UniParc UPI00017BA17E
UniProtKB Acc B4EMT0
UniProtKB ID B4EMT0_BURCJ
UniRef100 UniRef100_A0A0D1DNR1
UniRef50 UniRef50_Q398J3
UniRef90 UniRef90_Q398J3

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-9 efflux system outer membrane protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.36
Kyte-Doolittle Hydrophobicity Value -0.259
Molecular Weight (kDa) 42701.6
Isoelectric Point (pI) 7.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 425 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006645 (184 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1947
Search term: oqxA

References

Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825