Burkholderia cenocepacia J2315, BCAM1945

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1945
NCBI Locus TagQU43_RS64070
Name
Replicon chromosome 2
Genomic location 2159000 - 2160523 (- strand)
CommentMember of rnd-9 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-9
Comment Major RND-9 substrate is tobramycin, chlorhexidine (in biofilm grown cells)

Cross-References

RefSeq WP_012493447.1
GI 206563790
Entrez 6929576
GI 206563790
INSDC CAR55804.1
NCBI Locus Tag QU43_RS64070
NCBI Old Locus Tag BCAM1945
RefSeq WP_012493447.1,GeneID
UniParc UPI00017BA17C
UniProtKB Acc B4EMS8
UniProtKB ID B4EMS8_BURCJ
UniRef100 UniRef100_B4EMS8
UniRef50 UniRef50_A9BPE4
UniRef90 UniRef90_A0B1F2

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-9 efflux system membrane fusion protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -2.57
Kyte-Doolittle Hydrophobicity Value -0.136
Molecular Weight (kDa) 53033.3
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 285 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003035 (852 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1945

References

Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825