Burkholderia cenocepacia J2315, BCAM0927

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0927
NCBI Locus TagQU43_RS59010
Name
Replicon chromosome 2
Genomic location 1024872 - 1026032 (- strand)
Comment Major RND-8 substrate is tobramycin (in biofilm grown cells)
CommentMember of rnd-8 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-8

Cross-References

RefSeq WP_006489047.1
GI 206562782
Entrez 6930332
GI 206562782
INSDC CAR54784.1
NCBI Locus Tag QU43_RS59010
NCBI Old Locus Tag BCAM0927
RefSeq WP_006489047.1,GeneID
UniParc UPI00017B9C8E
UniProtKB Acc B4EF72
UniProtKB ID B4EF72_BURCJ
UniRef100 UniRef100_B4EF72
UniRef50 UniRef50_B4EF72
UniRef90 UniRef90_B4EF72

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-8 efflux system outer membrane protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 5.61
Kyte-Doolittle Hydrophobicity Value -0.139
Molecular Weight (kDa) 41140.6
Isoelectric Point (pI) 9.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 413 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006449 (194 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0927

References

Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis.
Sass A, Marchbank A, Tullis E, Lipuma JJ, Mahenthiralingam E
BMC Genomics 2011 Jul 22;12:373
PubMed ID: 21781329
Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825