Burkholderia cenocepacia J2315, BCAM0925

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0925
NCBI Locus TagQU43_RS59000
Name
Replicon chromosome 2
Genomic location 1020273 - 1021703 (- strand)
Comment Major RND-8 substrate is tobramycin (in biofilm grown cells)
CommentMember of rnd-8 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-8

Cross-References

RefSeq WP_006489053.1
GI 206562780
Entrez 6928660
GI 206562780
INSDC CAR54782.1
NCBI Locus Tag QU43_RS59000
NCBI Old Locus Tag BCAM0925
RefSeq WP_006489053.1,GeneID
UniParc UPI00017B9C8C
UniProtKB Acc B4EF70
UniProtKB ID B4EF70_BURCJ
UniRef100 UniRef100_B4EF70
UniRef50 UniRef50_Q8XT06
UniRef90 UniRef90_A0A095ECA9

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-8 efflux system membrane fusion protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 6.71
Kyte-Doolittle Hydrophobicity Value -0.198
Molecular Weight (kDa) 51713.0
Isoelectric Point (pI) 9.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 323 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006448 (199 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0925

References

Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis.
Sass A, Marchbank A, Tullis E, Lipuma JJ, Mahenthiralingam E
BMC Genomics 2011 Jul 22;12:373
PubMed ID: 21781329
Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.
Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T
Antimicrob Agents Chemother 2014 Dec;58(12):7424-9
PubMed ID: 25267676
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825