Burkholderia cenocepacia J2315, BCAM0223

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0223
NCBI Locus TagQU43_RS55535
Name
Replicon chromosome 2
Genomic location 270927 - 275579 (- strand)
CommentA BCAM0223::Tp mutant was deficient in hemagglutination, affected in adherence to vitronectin and in biofilm formation and showed attenuated virulence in the Galleria mellonella model of infection.

Cross-References

RefSeq YP_002232856.1
GI 206562093
Entrez 6928018
GI 206562093
INSDC CAR54081.1
NCBI Locus Tag QU43_RS55535
RefSeq WP_006489568.1,GeneID
UniParc UPI00017B9DF8
UniProtKB Acc B4EHQ5
UniProtKB ID B4EHQ5_BURCJ
UniRef100 UniRef100_A0A0D1DGE5
UniRef50 UniRef50_A0A0D1DGE5
UniRef90 UniRef90_A0A0D1DGE5

Product

Feature Type CDS
Coding Frame 1
Product Name
vitronectin-binding trimeric autotransporter adhesin
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -63.77
Kyte-Doolittle Hydrophobicity Value -0.087
Molecular Weight (kDa) 152052.8
Isoelectric Point (pI) 4.09

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Outer Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 88 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002926 (1913 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0223

References

A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.
Mil-Homens D, Fialho AM
PLoS One 2012;7(7):e41747
PubMed ID: 22848588
Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.
Mil-Homens D, Fialho AM
Front Cell Infect Microbiol 2011;1:13
PubMed ID: 22919579
Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage.
Mil-Homens D, Rocha EPC, Fialho AM
Microbiology 2010 Apr;156(Pt 4):1084-1096
PubMed ID: 20019083