Burkholderia cenocepacia J2315, BCAM0218

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM0218
NCBI Locus Tag	QU43_RS55510
Name
Replicon	chromosome 2
Genomic location	255662 - 258694 (- strand)

Cross-References

RefSeq	WP_006489553.1
GI	206562088
Entrez	6928013
GI	206562088
INSDC	CAR54076.1
NCBI Locus Tag	QU43_RS55510
NCBI Old Locus Tag	BCAM0218
RefSeq	WP_006489553.1,GeneID
UniParc	UPI00017B9DBC
UniProtKB Acc	B4EHQ0
UniProtKB ID	B4EHQ0_BURCJ
UniRef100	UniRef100_B4EHQ0
UniRef50	UniRef50_B1K7T6
UniRef90	UniRef90_B4EHQ0

Product

Feature Type	CDS
Coding Frame	1
Product Name	hybrid two-component system kinase-response regulator protein
Synonyms
Evidence for Translation
Charge (pH 7)	-7.02
Kyte-Doolittle Hydrophobicity Value	-0.082
Molecular Weight (kDa)	111059.2
Isoelectric Point (pI)	6.55

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001514 (1708 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM0218 Search term: hybrid two-component system kinase-response regulator protein

Human Homologs

References

A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence. Mil-Homens D, Fialho AM PLoS One 2012;7(7):e41747 PubMed ID: 22848588