Burkholderia cenocepacia J2315, BCAM0188 (cepR2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0188
NCBI Locus TagQU43_RS55360
Name
cepR2
Replicon chromosome 2
Genomic location 219739 - 220452 (- strand)

Cross-References

RefSeq WP_006490829.1
GI 206562058
Entrez 6927984
GI 206562058
INSDC CAR54046.1
NCBI Locus Tag QU43_RS55360
NCBI Old Locus Tag BCAM0188
RefSeq WP_006490829.1,GeneID
UniParc UPI00017B9D31
UniProtKB Acc B4EHM0
UniProtKB ID B4EHM0_BURCJ
UniRef100 UniRef100_B4EHM0
UniRef50 UniRef50_G7H9N0
UniRef90 UniRef90_G7H9N0

Product

Feature Type CDS
Coding Frame 1
Product Name
CepR2
Product Name Confidence: Class 1
Synonyms CepR2
Evidence for Translation
Charge (pH 7) 3.03
Kyte-Doolittle Hydrophobicity Value -0.023
Molecular Weight (kDa) 26093.8
Isoelectric Point (pI) 8.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5L10 TRANSCRIPTION 07/28/16 Crystal Structure of N-Acylhomoserine Lactone Dependent LuxR Family Transcriptionl Factor CepR2 from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA (STRAIN ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) 2.75 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 183 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003718 (1367 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0188
Search term: cepR2
Search term: CepR2

Human Homologs

References

A Burkholderia cenocepacia orphan LuxR homolog is involved in quorum-sensing regulation.
Malott RJ, O'Grady EP, Toller J, Inhülsen S, Eberl L, Sokol PA
J Bacteriol 2009 Apr;191(8):2447-60
PubMed ID: 19201791
X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia.
Kim Y, Chhor G, Tsai CS, Fox G, Chen CS, Winans NJ, Jedrzejczak R, Joachimiak A, Winans SC
Proteins 2017 Oct;85(10):1831-1844
PubMed ID: 28614901