Burkholderia cenocepacia J2315, BCAL3114 (wzx)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL3114
NCBI Locus TagQU43_RS52300
Name
wzx
Replicon chromosome 1
Genomic location 3403610 - 3404866 (+ strand)
CommentBelongs to the O antigen biosynthesis gene cluster

Cross-References

RefSeq WP_006485120.1
GI 206561460
Entrez 6933804
GI 206561460
INSDC CAR53438.1
NCBI Locus Tag QU43_RS52300
NCBI Old Locus Tag BCAL3114
RefSeq WP_006485120.1,GeneID
UniParc UPI00017B9951
UniProtKB Acc B4ECD5
UniProtKB ID B4ECD5_BURCJ
UniRef100 UniRef100_A0A0D1DF25
UniRef50 UniRef50_E5ATH9
UniRef90 UniRef90_G7HIS1

Product

Feature Type CDS
Coding Frame 1
Product Name
putative O-antigen exporter
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 19.64
Kyte-Doolittle Hydrophobicity Value 0.839
Molecular Weight (kDa) 45393.7
Isoelectric Point (pI) 10.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 53 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000748 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL3114
Search term: wzx

Human Homologs

References

Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis.
Ortega X, Hunt TA, Loutet S, Vinion-Dubiel AD, Datta A, Choudhury B, Goldberg JB, Carlson R, Valvano MA
J Bacteriol 2005 Feb;187(4):1324-33
PubMed ID: 15687196