Burkholderia cenocepacia J2315, BCAL2822 (bpeA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL2822
NCBI Locus TagQU43_RS50725
Name
bpeA
Replicon chromosome 1
Genomic location 3100527 - 3101801 (- strand)
Comment Major RND-4 substrates are aztreonam, chloramphenicol, fluoroquinolones, tobramycin
CommentMember of rnd-4 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-4

Cross-References

RefSeq WP_006497328.1
GI 206561159
Entrez 6932821
GI 206561159
INSDC CAR53122.1
NCBI Locus Tag QU43_RS50725
NCBI Old Locus Tag BCAL2822
RefSeq WP_006497328.1,GeneID
UniParc UPI00017B9981
UniProtKB Acc B4EA06
UniProtKB ID B4EA06_BURCJ
UniRef100 UniRef100_B4EA06
UniRef50 UniRef50_Q1CL40
UniRef90 UniRef90_B4EA06

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-4 efflux system membrane fusion protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 7.45
Kyte-Doolittle Hydrophobicity Value 0.042
Molecular Weight (kDa) 43445.1
Isoelectric Point (pI) 9.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 369 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002468 (670 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2822
Search term: bpeA

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825