Burkholderia cenocepacia J2315, BCAL1934 (arnA2)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS46215
Replicon chromosome 1
Genomic location 2133771 - 2134826 (+ strand)
CommentIn PMID:27597847: arnT, arnB, arnC, arnA1, arnA2, and BCAL1935 located in the arn gene cluster harbored significantly low frequencies of transposon insertions (TraDIS). They were therefore categorized as essential by the authors.


RefSeq YP_002231062.1
GI 206560298
Entrez 6932123
GI 206560298
INSDC CAR52235.1
NCBI Locus Tag QU43_RS46215
NCBI Old Locus Tag BCAL1934
RefSeq YP_002231062.1
UniParc UPI00002D76A4
UniProtKB Acc B4EB20
UniRef100 UniRef100_A0A071MNK8
UniRef50 UniRef50_Q8XZS6
UniRef90 UniRef90_A9AJX2


Feature Type CDS
Coding Frame 1
Product Name
putative UDP-4′-keto-5′-carboxypentose decarboxylase
Product Name Confidence: Class 2
Synonyms NAD-dependent epimerase/dehydratase family protein
Evidence for Translation
Charge (pH 7) -4.92
Kyte-Doolittle Hydrophobicity Value -0.259
Molecular Weight (kDa) 39451.7
Isoelectric Point (pI) 6.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SLG TRANSFERASE 06/24/11 Crystal structure of PbgP3 protein from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 95.4

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 525 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001696 (652 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1934
Search term: arnA2

Human Homologs


A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.
Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA
J Bacteriol 2007 May;189(9):3639-44
PubMed ID: 17337576
PubMed ID: 22742453
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
Williams GJ, Breazeale SD, Raetz CR, Naismith JH
J Biol Chem 2005 Jun 17;280(24):23000-8
PubMed ID: 15809294
Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS.
Wong YC, Abd El Ghany M, Naeem R, Lee KW, Tan YC, Pain A, Nathan S
Front Microbiol 2016;7:1288
PubMed ID: 27597847