Burkholderia cenocepacia J2315, BCAL1933 (arnA1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL1933
NCBI Locus TagQU43_RS46210
Name
arnA1
Replicon chromosome 1
Genomic location 2132827 - 2133774 (+ strand)
CommentIn PMID:27597847: arnT, arnB, arnC, arnA1, arnA2, and BCAL1935 located in the arn gene cluster harbored significantly low frequencies of transposon insertions (TraDIS). They were therefore categorized as essential by the authors.

Cross-References

RefSeq WP_006482868.1
GI 206560297
Entrez 6932122
GI 206560297
INSDC CAR52234.1
NCBI Locus Tag QU43_RS46210
NCBI Old Locus Tag BCAL1933
RefSeq WP_006482868.1,GeneID
UniParc UPI00017B9222
UniProtKB Acc B4EB19
UniProtKB ID B4EB19_BURCJ
UniRef100 UniRef100_B4EB19
UniRef50 UniRef50_F6G2W8
UniRef90 UniRef90_B4EB19

Product

Feature Type CDS
Coding Frame 1
Product Name
putative UDP-4-deoxy-4-formamido-l-arabinose formyltransferase
Product Name Confidence: Class 2
Synonyms putative formyltransferase
Evidence for Translation
Charge (pH 7) -2.42
Kyte-Doolittle Hydrophobicity Value 0.030
Molecular Weight (kDa) 33543.7
Isoelectric Point (pI) 6.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 593 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001695 (651 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1933
Search term: arnA1

Human Homologs

References

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.
Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA
J Bacteriol 2007 May;189(9):3639-44
PubMed ID: 17337576
PubMed ID: 22742453
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
Williams GJ, Breazeale SD, Raetz CR, Naismith JH
J Biol Chem 2005 Jun 17;280(24):23000-8
PubMed ID: 15809294
Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS.
Wong YC, Abd El Ghany M, Naeem R, Lee KW, Tan YC, Pain A, Nathan S
Front Microbiol 2016;7:1288
PubMed ID: 27597847