Burkholderia cenocepacia J2315, BCAL1676

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL1676
NCBI Locus TagQU43_RS44905
Name
Replicon chromosome 1
Genomic location 1833175 - 1834638 (+ strand)
Comment
Comment Major RND-3 substrates are nalidixic acid, ciprofloxacin, tobramycin, chlorhexidine
CommentMember of rnd-3 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-3

Cross-References

RefSeq YP_002230802.1
GI 206560038
Entrez 6933296
GI 206560038
INSDC CAR51974.1
NCBI Locus Tag QU43_RS44905
NCBI Old Locus Tag BCAL1676
RefSeq YP_002230802.1
UniParc UPI00017B9282
UniProtKB Acc B4E8U8
UniProtKB ID B4E8U8_BURCJ
UniRef100 UniRef100_B4E8U8
UniRef50 UniRef50_A6V6E6
UniRef90 UniRef90_A0K799

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-3 efflux system outer membrane protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.05
Kyte-Doolittle Hydrophobicity Value -0.042
Molecular Weight (kDa) 52110.0
Isoelectric Point (pI) 6.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 295 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001445 (1160 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1676

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825