Burkholderia cenocepacia J2315, BCAL1010 (nagZ2)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL1010
NCBI Locus Tag	QU43_RS41615
Name	nagZ2
Replicon	chromosome 1
Genomic location	1096806 - 1097834 (+ strand)

Cross-References

RefSeq	WP_006485604.1
GI	206559403
Entrez	6933288
GI	206559403
NCBI Locus Tag	QU43_RS41615
NCBI Old Locus Tag	BCAL1010
RefSeq	WP_006485604.1,GeneID
UniProtKB Acc	B4EA43
UniProtKB ID	B4EA43_BURCJ

Product

Feature Type	CDS
Coding Frame	1
Product Name	beta-hexosaminidase
Synonyms
Evidence for Translation
Charge (pH 7)	3.29
Kyte-Doolittle Hydrophobicity Value	0.019
Molecular Weight (kDa)	37035.2
Isoelectric Point (pI)	8.03

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4GNV	HYDROLASE	08/17/12	Crystal structure of beta-hexosaminidase 1 from Burkholderia cenocepacia J2315 with bound N-Acetyl-D-Glucosamine	BURKHOLDERIA CENOCEPACIA	1.5	X-RAY DIFFRACTION	100.0
5UTQ	HYDROLASE/HYDROLASE INHIBITOR	02/15/17	Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to PUGNAc	BURKHOLDERIA CENOCEPACIA	2.2	X-RAY DIFFRACTION	100.0
4G6C	HYDROLASE	07/18/12	Crystal structure of beta-hexosaminidase 1 from Burkholderia cenocepacia J2315	BURKHOLDERIA CENOCEPACIA	1.38	X-RAY DIFFRACTION	100.0
5UTP	HYDROLASE/HYDROLASE INHIBITOR	02/15/17	Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to N-ethylbutyryl-PUGNAc	BURKHOLDERIA CENOCEPACIA	2.2	X-RAY DIFFRACTION	100.0
5UTR	HYDROLASE/HYDROLASE INHIBITOR	02/15/17	Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-butyryl-4,5,6-trihydroxyazepane	BURKHOLDERIA CENOCEPACIA	2.15	X-RAY DIFFRACTION	100.0
4MSS	HYDROLASE/HYDROLASE INHIBITOR	09/18/13	Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane	BURKHOLDERIA CENOCEPACIA	1.8	X-RAY DIFFRACTION	100.0
6DTE	HYDROLASE	06/15/18	GlcNAc-inspired cyclophellitol bound to NagZ	BURKHOLDERIA CENOCEPACIA	1.929	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 468 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000980 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL1010 Search term: nagZ2 Search term: beta-hexosaminidase

Human Homologs

References